A Russian ICBM site is attacked just north of the Ukraine boarder. The nuclear warheads are missing! A Special Operations and Intelligence Community Task Force is rapidly put together to respond, but where it should deploy is unclear. A fire ravages a cosmonaut training facility in which five spacesuits disappear. And the Task Force finds a cache of detailed schematics of highly complex rocketry systems. The Task Force reaches out to Dr. Amy Sue Harrington of the Missiles and Space Intelligence Center in Huntsville, Alabama. To Dr. Harrington, it all adds up to the unthinkable: someone—someone extremely well funded—is taking aim at the International Space Station.

But Colonel Vladimir Lytokov and his team of mercenaries aren't planning to bring the ISS crashing to Earth. They're taking the fight to orbit, boarding the station and hijacking it. As the ISS traces its path across the heavens, Lytokov rains down destruction from above, effectively holding the entire globe hostage.