Set in late November 1827, the tale is begun by an unidentified narrator whose story is the loose outer frame for the central tale of Augustus Bedloe, a wealthy young invalid whom the narrator has known "casually" for eighteen years yet who still remains an enigma. Because of ongoing problems with neuralgia, Bedloe has retained the exclusive services of 70-year-old physician Dr. Templeton, a devotee of Franz Mesmer and the doctrine of animal magnetism, also called "mesmerism".