A twisty New York City-set mystery that sees Teddy Roosevelt's daughter, Alice Roosevelt, team up with Holmes and Watson to save the president from a kidnapping and attempted assassination on the eve of international peace talks. Holmes's British parlour tricks meet hard-boiled American noir in this pastiche for fans of Gareth Rubin's Holmes and Moriarty.

Celebrity socialite Alice Roosevelt is taking London by storm in 1905 when her letter containing sensitive details of upcoming peace talks between Japan and Russia is stolen. The case pulls Holmes from retirement, and with Alice's help the letter is retrieved.

After returning to the U.S., Alice goes missing. At Teddy Roosevelt's request, Holmes and Watson travel to New York where they discover Alice has turned detective herself, working undercover to thwart a kidnapping plot targeting her father. Her warnings are dismissed, but then the president is kidnapped. Alice and the detective duo join forces to search for her father, only to lose Holmes to the escaping kidnappers.

Alice proves herself the equal to the great detective by leading Watson in the rescue of Teddy Roosevelt as well as Holmes, but the stakes are higher than they realise. In a race against time, they must stop a plan to bomb the peace talks or risk an escalation of war on a global scale.