Political conflicts on Earth erupt into open hostilities between their colonies in space, with Xenomorphs as the ultimate weapon.

Political tensions boil over on Earth, spreading to the outer fringes of known space as the UK colony of New Albion breaks with the Three World Empire. When an oil-drilling facility on nearby LV-187 is destroyed, its French colonists slaughtered, the British are blamed. Military forces arrive from the Independent Core Systems and combat erupts.

Trapped in the middle are Cher Hunt and Chad Mclaren. Cher is trying to find out who was responsible for the death of her sister, Shy Hunt (of McAllen Integrations from Alien: Into Charybdis). At the same time Mclaren, accompanied by the synthetic known as Davis, follows in the footsteps of his late wife, Amanda Ripley, seeking to stop the weaponization of Xenomorphs. When a horde of the deadly aliens overwhelms both groups, however, their only hope may lie with Royal Marine Corps unit known as "God's Hammer."