The West made legends of two men. Heaven help the fool who dared to risk their wrath.

In a windswept campsite of the Fifth Cavalry Regiment, Russia's Grand Duke Alexis has arrived to experience the thrill of the buffalo hunt. His guides are Wild Bill Hickok and Buffalo Bill Cody--two heroic deadshots with a flair for showmanship and a thirst for adventure. But a train approaching from the East will provide Alexis a front-row seat to murder and mayhem that will set Hickok and Cody on the trail of cold-blooded killers.

The Orphan Train is nothing more than a traveling asylum for young urchins, stolen off the streets of New York's Lower East Side. Across the country they will be sold to the highest bidder--unless stopped in their tracks. Hickok and Cody take on the task, and begin a deadly cross-country journey tat will end in the wilds of Manhattan. Their quest for justice pits them against underworld thugs and raw corruption in a bloodbath that rocks the city. New York will never be the same again...