Dr. Catherine "Cathy" DeAngelis has shattered numerous glass ceilings in medicine for herself and generations of women she's mentored. Raised in 1940s hardscrabble Pennsylvania coal mining country, Cathy's unyielding determination and indomitable self-belief steamrolled medicine's entrenched sexism. In a life filled with "firsts," she was named the first woman Editor-in-Chief of JAMA---the Journal of the American Medical Association. Her six-decade career includes being one of the first female professors at the preeminent Johns Hopkins University and first Chair of their Pediatrics Division; Chair of the American Board of Pediatrics; and selection to the National Academy of Medicine, considered to be American Medicine's Hall-of-Fame. Cathy’s insight, leadership, sharp wit, and compassionate nature continue to make her a leading voice in the fight for gender equity, ensuring that women in medicine get the same opportunities and pay as their male peers. This is Dr. De’s amazing story, her life’s journey, in her own words.