Angela Guzman, head of a Columbian drug cartel, is known as "La Llorona", "The Crying Woman". According to legend, if you hear La Llorona's spirit crying, you are doomed to imminent death.

After inheriting the Guzman Cartel from her brother, Angela discovers that Rico Garcia - Muerte - was responsible for her brother's disappearance, and decides to set a trap for him in The Darien Gap. A sixty-mile strip of land between Panama and Columbia, it's a place of mountainous jungles , swamps, armed guerrillas and drug traffickers.

An inevitable standoff awaits Rico and his men. But after the dust settles, who will be the last man standing?