The House of Erzulie tells the eerily intertwined stories of an ill-fated young couple in the 1850s and the troubled historian who discovers their writings in the present day.

Emilie St. Ange, daughter of a Creole slaveowning family in Louisiana, rebels against her parents by embracing spiritualism and advocating the abolition of slavery. Isidore, her biracial, French-born husband, is horrified by the brutalities of plantation life and becomes unhinged by an obsessive affair with a notorious New Orleans vodou practitioner.

Emilie's and Isidore's letters and journals are interspersed with sections narrated by Lydia Mueller, an architectural historian whose fragile mental health further deteriorates as she reads.

Imbued with a sense of the uncanny and the surreal, The House of Erzulie also alludes to the very real horrors of slavery as it draws on the long tradition of the African-American Gothic novel.