Remo is set to teach a few lessons in hospitality at Florida's top tourist attraction, but his mind is made up. He is a free agent. No more CURE, no more trying to solve America's problems.

But the nation goes into a state of shock when a Lee Harvey Oswald look-alike is nailed trying to shoot the President and Remo can't ignore the call of duty—and a sense of déjà vu. Soon, a meddling television anchorwoman and strange transformations at the White House leave him feeling that he has landed a role in a bizarre Hollywood thriller.

With the direct line to the President still dead and Chiun trying to give away the secret of CURE, Remo and Smith are hard-pressed to protect the Man who threatened to shut down CURE for good...