"The Adventure of Wisteria Lodge" is one of the fifty-six Sherlock Holmes short stories written by Arthur Conan Doyle. One of eight stories in the volume His Last Bow, it is a lengthy, two-part story consisting of "The Singular Experience of Mr. John Scott Eccles" and "The Tiger of San Pedro", which on original publication in The Strand bore the collective title of "A Reminiscence of Mr. Sherlock Holmes".

Holmes is visited by a perturbed proper English gentleman, John Scott Eccles, who wishes to discuss something "grotesque". No sooner has he arrived at 221B Baker Street than Inspector Gregson also shows up, along with Inspector Baynes of the Surrey Constabulary. They wish a statement from Eccles about the murder near Esher last night. A note in the dead man's pocket indicates that Eccles said that he would be at the victim's house that night.