In the crumbling remains of a tunnel that was part of the Underground Railroad, a mysterious artifact reveals one of the darkest secrets of Africa's ancient past. Intrigued by the strange, encrypted stone, archaeologist Annja Creed opens a door to a world—and a legend—bound by a fierce and terrible force. She is not alone in her pursuit of the impossible.

A bloodthirsty African warlord, and an international corporate magnate exploiting a land, a culture and a people, are equally anxious to stake their claim on the relic's unknown power. Annja's odyssey deep into the primeval jungles of Senegal becomes a desperate race to stop those eager to unleash the virulence of the Spider God...