The journal Science (American Association for the Advancement of Science) in collaboration with Fondation Ipsen delivers international science webinars for the general public. In 2023, these webinars focused on advocacy in rare diseases. The Rare Disease Gazette is a magazine that broadcasts these discussions. In this edition, Erika Berg, PhD, hosts a Fireside Chat about the intersection between the FDA and rare disease, with Robert M. Califf, Commissioner of Food and Drugs at the United States Food and Drug Administration (FDA).