After Russian researchers develop a miracle cure for HIV, Trident Corporation begins the drug’s beta testing in America.

Sabrina gets tangled in an international web of intrigue, as terrorists are using the project as subterfuge for an attack on American soil. Soon after, a terrorist attack rocks Wall Street. It is time for the Nightcrawler to come out again.

But this time, Sabrina's lover Hoyt is in the thick of the action. With the war between drug cartels raging around them, can Sabrina bring the criminals to justice - and protect her fiancée?