Until April 14, 1865, John Wilkes Booth was one of the most famous actors of his time, and President Abraham Lincoln had even watched him perform. But his most significant performance at a theater did not take place on the stage. That night, Booth became one of history’s most infamous assassins when he assassinated President Lincoln at Ford's Theatre in Washington, D.C.

In 1880, Garfield ran as a Republican for president, and one of his supporters was a man named Charles Guiteau, who wrote and circulated a speech called “Garfield vs. Hancock” that aimed to rally support for the Republican candidate. Though few knew it, Guiteau’s family had already deemed him insane and attempted to keep him committed in an asylum, only to have him manage an escape from confinement. Garfield went on to narrowly edge Winfield Scott Hancock in the election, and Guiteau, harboring delusions of grandeur, believed he had helped tip the scales in Garfield’s favor.

President James Garfield had been assassinated just 20 years earlier, but McKinley didn’t worry about presidential security or his own safety, and that was the case in Buffalo. McKinley’s insistence on greeting the public and shaking hands allowed Czolgosz to walk up to him on September 6, 1901 at a public reception in the Temple of Music on the expo grounds and shoot him point blank, with one bullet grazing the president and another lodging in his abdomen.

In many ways, John Fitzgerald Kennedy and his young family were the perfect embodiment of the ‘60s. The decade began with a sense of idealism, personified by the attractive Kennedy, his beautiful and fashionable wife Jackie, and his young children. Months into his presidency, Kennedy exhorted the country to reach for the stars, calling upon the nation to send a man to the Moon and back by the end of the decade. But the idealism and optimism of the decade was quickly shattered, starting with Kennedy’s assassination in 1963.