St Angelus runs like a family: the workers take care of their own – a lesson the mysterious new assistant matron, Miss Van Gilder, is about to learn the hard way. Little Joe has had trouble breathing but the doctors don't take his sister Lily's concerns seriously, least of all Miss Van Gilder. The nurses of Lovely Lane have a secret which is dividing their close knit group and when Nurse Pammy Tanner once again breaks the rules, her actions threaten them all.