Microbial Resistance is a comprehensive exploration of the escalating crisis of antibiotic resistance, often resulting in "superbugs." It investigates how bacteria evolve to withstand our most powerful drugs, a phenomenon driven by factors like antibiotic overuse and horizontal gene transfer, where resistance genes spread rapidly among bacterial populations. This resistance poses a significant threat to public health, impacting routine medical procedures and the treatment of severe infections. The book delves into the genetic mechanisms that enable bacteria to resist antibiotics, such as enzymatic inactivation and target modification. It also highlights the increasing role of genomics in understanding and tracking the spread of resistance. The book examines the history of antibiotic use and the social and economic factors that contribute to the problem, advocating for a multifaceted approach that integrates insights from microbiology, public health, and policy.
The structure of the book progresses logically, beginning with fundamental principles of bacterial genetics and antibiotic action. It systematically explores resistance mechanisms, the spread of resistance genes, and the factors driving the selection of resistant bacteria. Finally, it discusses current strategies for combating resistance, including antibiotic stewardship and novel therapies, while addressing controversies like antibiotic use in agriculture.
