Chase Gray hasn't seen his daughter, Oakley, in two years. When he picks her up for a long-overdue getaway, the fourteen-year-old isn't keen on spending a week with her estranged father. Only one day into the road trip, their fragile reunion is interrupted when Oakley is kidnapped during a stop at a grocery store.

Tocho, a radical outcast of his tribe, is driven by visions of an ancient ritual. He believes the sacrifice of a young innocent girl under the Blood Moon will resurrect his dead ancestors. When he spots Oakley while robbing a store, he's convinced she's the one he needs.

Racing against time to track down his missing daughter, Chase teams up with his FBI friend, Miles, along with a ragtag group of volunteers. As supernatural forces rise and ancient spirits stir, Chase must battle not just monsters and madmen but the guilt of a past he can't change to avoid losing his daughter forever.