When he's not at the local pond trying to catch an uncatchable catfish named Bubba, "Catfish" Charlie Tuttle can usually be found at the Lone Star Outpost with his old pal Deputy Brazos and the post's lovely owner Julia Claire. Catfish has a sweet spot for Julia, so he's more than a little worried when she announces she's taking a stagecoach to Tombstone, Arizona. The stage runs through hostile territory, including a treacherous valley crawling with outlaws. Sure enough, Julia's stagecoach never makes it to Tombstone . . .

Even though Arizona is outside his jurisdiction, Catfish saddles up with Brazos and heads into outlaw country to find Julia. It's not long before they run into a gang of renegade soldiers led by a lunatic, Major Boneyard. Turns out Boneyard hid an arsenal of weapons on Julia's stagecoach, which he plans to sell to the Apache for gold. When their plan's revealed, the soldiers take Brazos hostage—leaving Catfish alone, outnumbered, and outgunned. Of course, that won't stop Catfish from trying to rescue his friends. Even if it leads him across the Mexican border—and into a full-blown war with the legendary El Serpiente, a poison-mean revolutionario who has a coiled serpent tattooed under his left eye . . .